Intra-Cytoplasmic Sperm Injection (ICSI)

ICSI is a fertilisation method that involves choosing a single sperm and injecting it into a mature egg using a very fine needle under microscopic control. ICSI assists the sperm to achieve fertilisation and is the recommended treatment for Male Factor Infertility.

What is ICSI?

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What is ICSI?

ICSI assists the sperm to achieve fertilisation and is the recommended treatment for Male Factor Infertility.

When is ICSI recommended?

ICSI treatment is recommended in the following cases:

Low sperm parameters (count, motility abnormal forms)or the presence of anti-sperm antibodies within the sample.
No sperm in the ejaculate due to previous vasectomy, blockage or absence of the Vas Deferens, early testicular failure or problems with ejaculation. Surgical sperm retrieval known as PESA and/or TESE, will be required in those cases.
Previous low fertilisation rate or failure to fertilise with conventional IVF.

Following the ICSI procedure, the injected eggs are incubated overnight and assessed the following morning by one of the embryology team for evidence of fertilisation. The average fertilisation rate following ICSI is similar to IVF with 60-70% of injected eggs fertilising normally. ICSI is the only treatment option for sperm samples that have been surgically retrieved.

Preparation for ICSI

Please note that the only difference between ICSI and conventional IVF is the laboratory procedure performed once the eggs and sperm have been obtained. The preparation for the person providing eggs for ICSI is identical to that of IVF. The person providing eggs will be required to undergo viral screening, drug stimulation, ultrasound monitoring and egg collection as for IVF.

The embryology team will be more than happy to assist you with any questions you may have regarding whether IVF or ICSI is the best treatment for you.

After the procedure

Your fertilised eggs are monitored closely and our embryology team will assess the best day to transfer the developing embryo(s) into the womb.

You can be assured of the best possible treatment throughout these procedures and of our continued support and care.

Treatment	Cost*
Treatment Cost	Average Cost (£)
New consultation – heterosexual and same-sex couples	£400
Includes semen analysis + Hyaluron Binding Assay (HBA) and Anti Mullerian Hormone (AMH) test
New consultation – single lady	£350
Includes Anti Mullerian Hormone test (AMH)
Female screening	£187
(HE2a)FBC, HIV, Hep A, Hep B (Core & Surface antigen), Hep C, (NAT/PCR) Chlamydia, Rubella, HB electrophoresis
Partner screening	£137.50
(HE1a)HIV, Hep A, Hep B (Core & Surface antigen), Hep C, Chlamydia
Saline Infusion Sonography	£485
A saline infusion sonogram (SIS, saline sonography) is an ultrasound test to check if the endometrial cavity (inside of the uterus) appears normal.
Counselling	Free
Free
HFEA fee – IVF/ICSI	£85
IVF treatment with ICSI – Intra cytoplasmic sperm injection	£5,000
ICSI is part of in vitro fertilisation (IVF). It involves the sperm being injected directly into the egg. (includes medical and nursing care, monitoring and scans, Sedation, Egg collection, Laboratory procedures, ICSI procedure, Embryo transfer & Counselling)

Medication - based on an average length of stimulation	£1,800-£2,700
Drugs based on x 12 inj @ 150iu per day
Suprecur (3 bottles)	£93
Cetrotide (8 vials)	£240
Stimulation x 12 days	£744
Cyclogest (2 boxes)	£48
Azithromycin 250mg (1 box of 4)	£9.35
Gonasi x 2 / Ovitrelle	£60
Sub total	£1,178
Drugs based on x 12 inj @ 450iu per day
Suprecur (3 bottles)	£93
Cetrotide (8 vials)	£240
Stimulation x 12 days	£2,232
Cyclogest (2 boxes)	£48
Azithromycin 250mg (1 box of 4)	£9.35
Gonasi x 2 / Ovitrelle	£60
Sub total	£2,666
Extra medication costs, if needed (for 2 weeks until pregnancy test).	Average Cost (£)
Aspirin 75 mg daily (1 box with 56 tablets)	£2
Prednisolone 20 mg daily ( 2 boxes of 28 tablets each)	£16
Prednisolone – Prednisolone is a glucocorticoid which is produced by your adrenal gland in your kidney. It has a good anti-inflammatory effect and is generally used in auto-immune (non-infectious) inflammatory conditions. It is typically prescribed in fertility treatment for patients who have had multiple miscarriages, aiming to reduce cells that may attack the fetus.
Clexane 20mg daily (2 boxes of 10 injections each)	£84
Clexane – Clexane is a low molecular weight heparin. Heparin is an anticoagulant which prevents clot formation in the blood. Clexane is thought to help prevent blood clots from forming in the embryo and placenta.
Prontogest 100 mg daily ( 5 boxes with 3 ampoules each)	£100
Prontogest – Prontogest is an effective way of administering progesterone. However, it needs to be administered in the buttock as an intramuscular injection, and you will need to have someone who is prepared to administer this for you, as you will not be able to do so yourself.
Lubion 25mg daily (2 boxes with 7 vials each)	£150
Pregnancy scan	£215
An early pregnancy scan is performed in the first 5-11 weeks of pregnancy and will: Determine the presence and location of a pregnancy Confirm the fetal heartbeat (possible after 7 weeks of pregnancy) Check the viability of a pregnancy (the likelihood of problems or complications) Diagnose a multiple pregnancy (singleton, twins, triplets or more) Calculate your estimated due date (EDD)